Sunday, April 22, 2012

How would you explain the connection between glucose entering the body and energy created by the body to a friend, using your new biochemistry knowledge?


Glucose
(wikipedia)

To create energy, glucose enters the body and a phosphate attaches to the glucose molecule. This attachment in turn creates glucose-6-phophate. During this step there is a loss of energy because the phosphate that attaches comes from ATP and is converted into ADP. From here, the glucose-6-phosphate rearranges into fructose-6-phosphate and yet another phosphate attaches, causing energy loss, yielding fructose 1, 6-diphosphate. 
The new product then splits into two separate molecules, dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Dihydroxyacetone phosphate rearranges into its isomer form glyceraldehyde 3-phosphate (so now there are two of the same molecules). The two glyceradehyde 3-phosphates molecules then create two 1, 3-bisphosphoglycerate molecules which each lose a phosphate. This yields two 3-phosphoglycerate molecules which will create 2 molecules of ATP (net of 0 ATP created). 
Glycolysis
(wikipedia)
At this point, these molecules will rearrange into two molecules of 2-phosphoglycerate then water loss will occur and they will become phosphoenolpyruvic acid molecules. They will each lose a phosphate which in turn creates 2 ATPs. The phosphoenolpyruvic acid molecules will either become Acetyl CoA, lactic acid, or ethanol and carbon dioxide. When it turns into the Acetyl CoA, the new molecules enter the Krebs Cycle where a significant amount of energy is created because they lose phosphate groups resulting in ATPs. This ATP is then stored in the muscles of the body.

1 comment:

  1. Great explanation. The figures make it even a lot more understandable.

    ReplyDelete